Gene Mayfield led the Panthers to the school's first state championship title in 1965.  He left Permian in 1971 and was head coach at West Texas State from 1971-76.
 
Gil Bartosh left Permian after the '72 state title season to Texas A&M.  After which, he was head coach at Texas-El Paso for three seasons.
 
John Wilkins left the coach's office in 1985 and moved downtown as the school district's athletic director.  Wilkins took the athletic director job at Midland Trinity in 1998, and found himself back on the sideline as head coach until Spring 2002.
 
After winning a state title, Gary Gaines moved to Texas Tech where he served as linebacker coach from 1990-93.  After head coaching at Abilene Christian University, he returned to ECISD as Athletic Director.
 
Tam Hollingshead left Permian and headed to AggieLand in 1994.  Hollingshead celebrated nine seasons as tight end coach at Texas A&M, before taking the head coaching position with the Temple Wildcats.  He is now at Rockwall Heath.
 
Randy Mayes left Permian in 1999 and is at Flower Mound Marcus as a physical education teacher.

T.J. Mills coached the Panthers to a 15-15 record in his three season tenure.  He returned to the Texas coast as LaPorte's head coach.

Scott Smith spent two seasons as Permian's head coach.  In Smith's first season, the Panthers went 6-4.  In his second year went 4-6.

Darren Allman is making his return to Permian as the 11th head coach in the school's history.  Allman is the first to not only play but also head coach the Panthers.